Is this research peptide third-party tested?

Yes. Every batch is independently tested by ILS Labs, an ISO/IEC 17025-accredited laboratory, for identity and purity, and a Certificate of Analysis (COA) is available for each batch.

Can I see the Certificate of Analysis (COA)?

Yes. Batch-specific Certificates of Analysis are published in the NGPeptide COA Library at https://ngpeptide.com/coa-library/.

What does "research use only" mean?

All products are supplied strictly for laboratory and in-vitro research use only (RUO). They are not intended for human or veterinary use, and no dosing or administration guidance is provided.

How is my order shipped?

Orders ship domestically within the USA. Products should be handled and stored following standard laboratory practice for research peptides.

⚠️ FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from clinical trials for educational reference.

Popular Peptides

MOTS-C

Name: MOTS-C
Brand: Next Gen Peptides
SKU: 561
Price: 80 USD
Availability: InStock

Third-Party Tested COA Available

Quantity

Price

$80.00

Select Size

Quick Quantity Selection

COA

In stock – Ships same day

SSL Secured Secure Checkout Guaranteed Delivery Third-Party Tested

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

Latest

99.86%

Purity

VariantMOTS-C

Lot #MS40-08

Labeled40mg

Actual41.28mg

TestedJun 28, 2026

View COA

N/A%

Purity

VariantMOTS-C 30mg

Lot #MTC-LD-01

Labeled30mg

Actual30mg

TestedJun 12, 2026

View COA

99.04%

Purity

VariantMOTS-C 40mg

Lot #MTS40-07

Labeled40mg

Actual41.39mg

TestedMay 23, 2026

View COA

Compound Information

Technical specifications

Molecular Profile

What Is MOTS-C?

Type 1627580-64-6

CAS Number 1627580-64-6

Molecular Weight 2174.6 g/mol

Molecular Weight (Cu) N/A

Amino Acids 16 Amino Acids

Sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Met-Cys-Ser-Ser-Leu-Glu

Formula $C_{101}H_{152}N_{28}O_{22}S_{2}$

Storage Requirements

Stability Information

Lyophilized powder; keep sealed, dry, and protected from light.Store at a stable temperature and minimize warming/cooling cycles.After reconstitution, avoid repeated freeze–thaw cycles.

Lyophilized Powder -20°C

Reconstituted 2-8°C

About MOTS-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a unique mitochondrial-derived peptide that functions as a systemic signaling molecule. In research settings, it is primarily studied for its role in metabolic homeostasis and its ability to regulate the AICAR-AMPK pathway. MOTS-c is unique because it is encoded in the mitochondrial DNA rather than the nuclear DNA. Research indicates that it targets skeletal muscle to enhance glucose metabolism and increase fatty acid oxidation. It is widely utilized in studies involving aging, obesity, and physical performance, as it appears to mimic many of the physiological benefits of exercise at a cellular level. This high-purity lyophilized reagent provides a consistent standard for exploring mitochondrial-to-nuclear communication.

Mechanism of Action

The mechanism involves MOTS-c signaling from the mitochondria to the nucleus. Once released, it activates the AMPK (AMP-activated protein kinase) pathway in skeletal muscle. This activation triggers the translocation of GLUT4 to the cell membrane, significantly increasing glucose uptake independent of insulin. Furthermore, it promotes mitochondrial biogenesis and enhances the oxidation of fatty acids, effectively switching the cell into a more efficient metabolic state during research assays.

What Research Has Shown

Metabolic Research

98 Purity Percentage (HPLC Verified)

Glucose Uptake & Insulin Sensitivity

MOTS-c Treated Group 84.5%

Control Group 28.0%

Trial details: Investigative studies focusing on the activation of the AMPK pathway and the regulation of mitochondrial bioenergetics in aging and obesity models.