⚠️ FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
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5-Amino-MQ Capsules
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Compound Information
Technical specifications
What Is 5-Amino-MQ Capsules?
Stability Information
About 5-Amino-MQ Capsules
5-Amino-MQ (5-Amino-1-methylquinolinium) is a small-molecule compound studied as a membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme involved in nicotinamide methylation and related biochemical pathways associated with cellular methyl-donor availability and NAD+ metabolism. In controlled laboratory settings, 5-Amino-MQ is investigated to characterize NNMT activity, enzyme-inhibition mechanisms, metabolic signaling pathways, mitochondrial-associated processes, and cellular bioenergetics. Supplied in a consistent 50 mg research format for qualified laboratory, analytical, and in-vitro investigation only. Not intended for human or animal consumption, therapeutic use, diagnostic use, or clinical application.
Mechanism of Action
The mechanism involves 5-Amino-MQ binding to the NNMT enzyme, preventing the methylation of nicotinamide into 1-methylnicotinamide (MNA). By blocking this pathway, the cell conserves NAD+ and SAM, which are critical for energy metabolism and epigenetic regulation. This increase in NAD+ availability triggers the SIRT1 pathway, leading to enhanced fatty acid oxidation and improved contractile performance in skeletal muscle cells within research assays.
What Research Has Shown
Metabolic and Muscle Homeostasis
Findings from NNMT inhibition investigations
Research Highlights
Product Specifications
- Molecular Formula
- C10H11N2+
- Molecular Weight
- 159.21g/mol
- Sequence
- N/A
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Soluble in water, bacteriostatic water
- Storage
- -20°C (lyophilized), 2-8°C (reconstituted)
Research Studies
Frequently Asked Questions
It acts as a selective inhibitor of the enzyme NNMT, which plays a major role in energy metabolism and fat storage.
By inhibiting NNMT, it increases intracellular NAD+ levels, which enhances mitochondrial function and energy expenditure.
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- Third Party Tested
- ≥99% Purity